The Emory Biomarker Service Center (EBSC) is the synergistic integration of the former Center for Medical Genomics (CMG), Yerkes Microarray Core (YMC), and the Winship Cancer Institute Microarray Core (WCIMC) facilities into one lab with complementary capabilities, goals, and services. By integrating into one shared core and facility we have leveraged knowledge and resources to provide comprehensive services for investigators at Emory University, Emory Healthcare, and the entire health care and research communities.

• Place state of the art tools and technologies within reach of investigators catalyzing translational disease research through basic science
• Assist investigators in novel multi-disciplinary approaches in genomic, epi-genomic, proteomic, and pharmacogenomic fields for the efficacious and safe application of medicine through both prognostic and predictive biomarkers

No association between polymorphisms in LEP, LEPR, ADIPOQ, ADIPOR1, or ADIPOR2 and postmenopausal breast cancer risk.

Teras LR, Goodman M, Patel AV, Bouzyk M, Tang W, Diver WR, Feigelson HS.

Identification of a novel small molecule HIF-1alpha translation inhibitor.

Narita T, Yin S, Gelin CF, Moreno CS, Yepes M, Nicolaou KC, Van Meir EG.

Predicting endocrine responsiveness: novel biomarkers on the horizon.

Kerstann KF, Bouzyk M, Abramovitz M, Leyland-Jones B.

Decreased NK cell frequency and function is associated with increased risk of KIR3DL allele polymorphism in simian immunodeficiency virus-infected rhesus macaques with high viral loads.

Bostik P, Kobkitjaroen J, Tang W, Villinger F, Pereira LE, Little DM, Stephenson ST, Bouzyk M, Ansari AA.

Prostaglandin F2alpha promotes muscle cell survival and growth through upregulation of the inhibitor of apoptosis protein BRUCE.

Jansen KM, Pavlath GK.

Genome-wide promoter analysis of the SOX4 transcriptional network in prostate cancer cells.

Scharer CD, McCabe CD, Ali-Seyed M, Berger MF, Bulyk ML, Moreno CS.

Genetic variation in candidate obesity genes ADRB2, ADRB3, GHRL, HSD11B1, IRS1, IRS2, and SHC1 and risk for breast cancer in the Cancer Prevention Study II.

Feigelson HS, Teras LR, Diver WR, Tang W, Patel AV, Stevens VL, Calle EE, Thun MJ, Bouzyk M.

Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells.

Guo L, Zhong D, Lau S, Liu X, Dong XY, Sun X, Yang VW, Vertino PM, Moreno CS, Varma V, Dong JT, Zhou W.

The endothelin-1 G5665T polymorphism impacts transplant-free survival for single ventricle patients.

Kirshbom PM, Mahle WT, Joyner RW, Leong T, Wilson M, Kogon BE, Kanter KR, Bouzyk MM.

Optimization of RNA extraction from FFPE tissues for expression profiling in the DASL assay.

Abramovitz M, Ordanic-Kodani M, Wang Y, Li Z, Catzavelos C, Bouzyk M, Sledge GW Jr, Moreno CS, Leyland-Jones B.

Intercenter reliability and validity of the rhesus macaque GeneChip.

Duan F, Spindel ER, Li YH, Norgren RB Jr.

Genome-wide analysis of the homeobox C6 transcriptional network in prostate cancer.

McCabe CD, Spyropoulos DD, Martin D, Moreno CS.

Restoration of connexin26 protein level in the cochlea completely rescues hearing in a mouse model of human connexin30-linked deafness.

Ahmad S, Tang W, Chang Q, Qu Y, Hibshman J, Li Y, Söhl G, Willecke K, Chen P, Lin X.

A new method for identifying informative genetic markers in selectively bred rats.

Weinshenker D, Wilson MM, Williams KM, Weiss JM, Lamb NE, Twigger SN.

Molecular differences in triple negative breast cancer between race/ethnicities.

Bouzyk MM, Barwick BG, Abramovitz M, Kodani M, Oprea G, Tang W, Moreno CS, Leyland-Jones B

Development of a Prognostic Biomarker Protein Array for the Cerebrospinal Fluid (CSF) of Brain Tumor Patients.

Li Y, Khwaja F, Wagar N, Bouzyk M and Van Meir EG

MicroRNA Involvement in Breast Cancer Multidrug Resistance

Liang Z, Wu H, Xia J, Li YH, Wagar N, Zhu A, Wang S, Blevins D, Yoon Y, Reddy S, Southerland J, Scala S, Bates S, Shim H.

The Role of Sex Hormone-Binding Globulin (SHBG) in the Androgen Response of Human Prostate Cancer Cells

Li YH, Nakhla A, Hryb D, Friedman R, Xiang J, Wagar N, Rosner W, Romas N, Klatt D and Kahn S

Genome-wide Analysis of Gene Expression Profiles Induced by Norwalk Virus Capsid Protein Gene

Liu P, Li YH, Hsiao H, Wagar N, Moe CL

Microarray Analysis of Apoptosis-associated Pathways in Connexin30-deficient Cochlea

Tang W, Li YH, Qu Y, Wagar N, and Lin X

The Center for Medical Genomics Overview

Wilson M

The Winship Cancer Institute Microarray Core Facility

Kodani M

Yerkes Microarray Core

Wagar N, Li YH